Research & Technology
01
Scientific Foundation
01
Overview: How it works
Codonscope is composed of two core components:
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A generative module with models for designing regulatory sequences (5’ and 3’ UTRs) and coding sequence candidates from protein sequence.
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A coding sequence optimizer that searches an enormous design space to find mRNA sequences with superior stability, translation efficiency, and longevity — without changing the protein sequence.
Together, these modules enable the joint design of entire mRNA molecules with higher biological fitness.
02
Validated Performance
Codonscope's designs have demonstrated:
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8× increase in protein expression over wild-type mRNAs
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2–3× more protein than traditional codon-optimized benchmarks
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2× longer expression in immune-competent cells (e.g. Jurkat T cells)
These results were observed across different cell systems, including HEK and Jurkat cells, validating both stability and translation enhancements.
03
Multi-Parameter Optimisation
Codonscope doesn't just optimize for codon usage. It incorporates multiple variables:
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Minimum Free Energy (MFE) for secondary structure prediction
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Average Unpaired Probability (AUP) to reduce hydrolysis-prone regions
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Sequence stability models to prolong protein expression
This multi-layered optimization approach delivers mRNAs that are not only efficient, but resilient and therapeutically relevant.
04
Therapeutic-Grade Design
In a proof-of-concept experiment, Codonscope was used to optimize mRNA encoding a chimeric antigen receptor (CAR). Results showed:
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2× more CAR-expressing cells
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2× higher protein levels at 48 hours
This suggests strong potential for applications in cell therapies, mRNA vaccines, and synthetic biology.
02
Collaboration Opportunities
01
Project Sky Guardian
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02
NextGen Fighter Jet Development
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03
Space Debris Removal Technology
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04
Hypersonic Missile Defense Systems
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05
Space Situational Awareness (SSA)
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06
Autonomous Drone Swarm Technology
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